![]() These results demonstrate that the novel, natural gum, H. Addition of either sodium bicarbonate or tartaric acid, as well as higher amounts of CPM, did not affect the mucoadhesive bond strength. The force of detachment for the mucoadhesive buccal tablets containing 22 mg of Hakea and either 25 and 40 mg CPM, and 32 mg Hakea and 40 mg CPM increased from 1.64+/-0.47 to 7.32+/-0.34 N, 1.67+/-0.30 to 7.21+/-0.36 N, and 2.93+/-0.73 to 7.92+/-0.60 N, respectively from 5 to 90 min following application to excised intestinal mucosa. Following the application of the mucoadhesive buccal tablets, the following values for several pharmacokinetic parameters were obtained. The strength of mucoadhesion of the tablets was also quantitated in terms of the force of detachment as a function of time. The resulting plasma CPM concentration versus time profiles were determined following buccal application of the tablets in rabbits. Flat-faced core tablets containing either 22 or 32 mg of Hakea and 40 or 25 mg of chlorpheniramine maleate (CPM) per tablet with either sodium bicarbonate or tartaric acid in a 1:1.5 molar ratio were formulated using a direct compression technique and were coated with Cutina(R) on all but one face. the continuous reduction in the terminal release rate with time.read more read lessĪbstract: The objective of this study was to evaluate the gum from Hakea gibbosa (Hakea) as a sustained-release and mucoadhesive component in buccal tablets following their application to the buccal mucosa of rabbits. The erosion mechanism can be used to lessen one of the major problems associated with hydrophobic and plastic matrix tablets, i.e. However, the shape of the release curve was altered slightly in those tablets that eroded to a greater extent and residuals analysis illustrated a better fit with the latter model. Mathematical modeling showed an equally good fit between the data and (a) the Higuchi model, or (b) a model that took into account diffusion, relaxation of the polymer, and erosion. It was possible to sustain the release of a therapeutic dose of theophylline over a 12-h period. The theophylline to ethylcellulose ratio and the tablet hardness were found to influence the rate of drug release. The release rate decreases because the external layers of the tablet become depleted and water must penetrate the deeper layers of the tablet to reach the remaining drug. This property was utilized in an attempt to decrease the attenuation of the release rate that is observed with matrix tablets that follow the Higuchi pattern of drug release. In addition, matrices of this polymer display slow surface erosion which can be enhanced by the incorporation of a swelling agent. Ethylcellulose compacts well and also retards drug release. UNSW Learning and Teaching Forum, Invited Speaker: 2013, 2014, 2015.Abstract: In an effort to reduce production costs, a simple, direct compression sustained release formulation consisting, principally, of the drug (theophylline) and ethylcellulose was investigated.UNSW Learning and Teaching Connections Seminar, Invited Seminar: 2012, 2015, 2016.UNSW Scientia Education Lecture, November 2020.Nalini is currently supervising five HDR students. Her broad and deep expertise and understanding of medicine and health, equips Nalini to interrogate advances in medical technologies, enable translation to practice, and advocacy. Her PhD (2009) in the cell biology of wound healing and management, built on her Masters in Clinical Anatomy and Imaging. Nalini’s research focusses on medical imaging and radiomics for diagnostic systems, blended/hybrid program and curriculum design, immersive technologies such AR/VR and 3D printing, and inclusive education. Nalini is a Fellow of ANZAHPE and the UNSW Scientia Education Academy. ![]() Nalini is the Chair of the International Program for Anatomical Education (FIPAE) of the IFAA, and an Associate Editor of Anatomical Sciences Education (Impact Factor, 5.9). She has several awards (Faculty, Vice-Chancellor, Australian Award for University Teaching) for her contributions to higher education. ![]() She has more than 25 years’ experience in educational innovation and design in medicine and health programs in several countries. Nalini’s research focusses on medical imaging, hybrid/digital education, and inclusive education. She is the co-founder of the Health Universities Initiative, which frames a whole-of-university approach to student success and wellbeing. She focuses on curriculum design, enhancing the student experience, and SoTL. Professor Nalini Pather is the Associate Dean Education, Innovation at Medicine & Health, UNSW. ![]()
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